1. Indian J Exp Biol. 1996 Jun;34(6):531-4.

Neuropharmacological studies on Fusarium toxins-III: Neurochemical investigations
on total toxin extracts from F. moniliforme and F. oxysporum.

Ganguli S(1), Hota D, Goel RK, Acharya SB, Bhattacharya SK.

Author information: 
(1)Department of Pharmacology, Banaras Hindu University, Varanasi, India.

Neurochemical effects of different fusarial toxins elaborated from F. moniliforme
(FM) and F. oxysporum (FO) were investigated. FM showed significant nonspecific
and irreversible monoamine oxidase (MAO) inhibition which was qualitatively
comparable to that induced by nialamide, a nonselective MAO inhibitor. FO did not
exhibit any significant MAO inhibitory effect. FM produced a dose related
increase in monoamine concentrations (dopamine, noradrenaline and
5-hydroxytryptamine) in different rat brain areas namely, diencephalon-midbrain, 
caudate nucleus and pons-medulla. FO, on the contrary, produced marked increase
in dopamine concentration in the caudate nucleus with concomitant reduction in
noradrenaline levels in diencephalon-midbrain and pons-medulla with little effect
on 5-HT concentration. The neurochemical effects of FM and FO are consonant with 
the earlier reports on the neuropharmacological profile of these toxins. Thus, FM
was reported to have nialamide like activity, whereas FO actions were
dopaminergic in nature.

PMID: 8792642  [PubMed - indexed for MEDLINE]